Genes critical for white blood cell development

The Lieschke group studies the haemopoietic system and leukocytes. The haemopoietic system is a collection of organs and tissues (bone marrow, spleen, lymph nodes etc.) responsible for the production of blood in the body. Leukocytes (white blood cells) are the keys cells involved for counteracting foreign substances and disease. They also play a major role in determining whether tissue repairs and regenerates rather than scars after injury. Using the zebrafish as a model organism, the Lieschke group studies blood cell development and function. In particular, we look at mutant zebrafish with faulty blood cell development to find insights into the genes that regulate the haemopoietic system. These mutant zebrafish also assist with understanding the role of leukocytes in inflammation and healing. This information is used to create infection models that stimulate leukocytes in action, which helps the group investigate the host-pathogen response.