Description
In this project, in collaboration with Professor Ross Hannan (ANU), we will study the structure of Upstream Binding Factor (UBF) in complex with ribosomal RNA genes (rDNA). The work will utilize Correlative Light and Electron Microscopy (CLEM) and Electron Tomography (ET) experiments. Understanding the structure of UBF/rDNA will be central for developing strategies to disrupt ribosome biogenesis in the context of a wide range of human cancers.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
structural biology, cancer, rDNA, electron microscopy, electron tomography, ribosome
School
Biomedicine Discovery Institute (School of Biomedical Sciences) » Biochemistry and Molecular Biology
Available options
PhD/Doctorate
Masters by research
Honours
BMedSc(Hons)
Time commitment
Full-time
Part-time
Top-up scholarship funding available
Yes
Year 1:
$1000
Physical location
Monash Clayton Campus
Research webpage
Co-supervisors
Assoc Prof
Alex de Marco
Prof
Ross Hannan
(External)