Identification of new therapeutic targets to control invasive behaviours of brain cancers

Brain cancers are notoriously aggressive, and current treatments are often ineffective at preventing disease progression. This research project focuses on identifying new therapeutic targets to control the invasive behaviours of brain cancers. Using various experimental approaches, we investigate the mechanisms behind the progression of brain cancers and aim to identify novel therapeutic targets that could potentially prevent or slow the spread of the disease. By elucidating the signalling pathways involved in cancer invasion, we hope to develop more effective treatments that can improve the outcomes of patients with brain cancer. Our recent research has been on medulloblastoma, the most common malignant childhood brain tumour. This project uses wide range of experimental approach including in vitro and in vivo models, cell imaging, cell-based assays, RNA and protein analyses, drug screening, omics studies, and patient data analysis.