Description
Project description: Impaired differentiation is a common feature of cancer. We have recently demonstrated the differentiation potential of histone deacetylase inhibitors (HDACi) in paediatric (rhabdoid tumours) and adult (lung adenocarcinoma) solid tumours that are genetically defined by mutations in the SWI/SNF chromatin remodelling complex. Recent genomic studies have shown that mutations in subunits of this complex occur in at least 20% of all cancer. Using preclinical models of SWI/SNF-deficient and intact cancers, the successful candidate will investigate the mechanisms of epigenetic-mediated differentiation and apply these findings to a broader clinical context.
Please email me directly with enquiries: jason.cain@hudson.org.au.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
epigenetics, cancer, peadiatrics, brain, lung
School
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Molecular and Translational Sciences
Available options
PhD/Doctorate
Honours
Time commitment
Full-time
Top-up scholarship funding available
No
Physical location
Monash Health Translation Precinct (Monash Medical Centre)
Co-supervisors
Dr
Vijesh Vaghjinai