Pathophysiology and mechanisms of diabetes and metabolic and reproductive disorders

These studies examine the mechanistic pathways underlying insulin-resistant states (including diabetes, polycystic ovary syndrome and pregnancy), with a focus on hormonal physiology, lipid metabolism and chronic low-grade inflammation. Major current projects include: - Hormonal physiology and lactation in metabolic insulin resistant conditions including polycystic ovary syndrome, gestational diabetes and pre-existing type 1 and 2 diabetes - Does Metformin alter microbiota composition in polycystic ovary syndrome? Exploration of mechanisms of action - Metformin mechanisms of action in pregnancy: explorations of ethnic and genetic variations - Exploration of lipid metabolism as a potential pathway by which dietary intake impacts on gestational diabetes and pregnancy outcomes - Examining the cross-talk between lipid metabolism, inflammation, and other novel mechanisms underlying insulin resistance in obesity and metabolic disorders These projects encompass a multidisciplinary approach with ample opportunities for students to obtain key research knowledge and skills. Multiple methodologies will be utilised to achieve the research aims, spanning across the research continuum from mechanistic and epidemiological research, to clinical trials, large-scale meta-analyses, and translational activities. Ideally, this work is suited for students with an interest in metabolism and reproducti health and with a passion for delivering research with impact. Given the timelines for most of these projects, Honours or Masters students may only be considered if they plan to progress to a PhD.