Description
Gamma-aminobutyric acid (GABA) produced by Glutamic Acid Descarboxylase (GAD) is the most abundant neurotransmitter inhibitor in the CNS and is critical for the control of movements, development, learning and recovery from brain damage. Neurological conditions, such as anxiety, autism and post-traumatic stress disorder, are intimately related to imbalance of GABA homeostasis. In this project, we aim to structurally characterize GAD in complex with molecules that alter the rate of GAD activity. We anticipate that these molecules may be of utility in controlling GAD function in the context of anxiety and panic disorders.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
neurotransmitter inhibitor, GABA homeostasis, anxiety, panic disorder, drug discovery, structural biology
School
Biomedicine Discovery Institute (School of Biomedical Sciences) » Biochemistry and Molecular Biology
Available options
PhD/Doctorate
Masters by research
Honours
BMedSc(Hons)
Time commitment
Full-time
Part-time
Top-up scholarship funding available
Yes
Year 1:
$1000
Physical location
Monash Clayton Campus
Research webpage
Co-supervisors
Dr
Ruby Law